Estrogen receptor modulators and uses thereof

US8455537B2 · kind B2 · utility

Assignee

• University of Medicine and Dentistry of New Jersey · US

Inventors

• William J. Welsh · New Brunswick, US
• Ching-Yun Wang · Cincinnati, US
• Ni Ai · Piscataway, US

Key dates

• Filing date: Jun 21, 2011
• Grant date: Jun 4, 2013
• Expiry date: Jun 21, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method for preventing, diagnosing, or treating a condition mediated by an estrogen receptor by administering to a patient in need thereof an effective amount of a compound of formula I, II, or a combination thereof: wherein R1, R3, R4, and R5 are independently selected from H, OH, and ORa; R2 is selected from H, OH, and (C═O) (C1-7)alkyl; Ra is (C1-7)alkyl or (C═O)(C1-7)alkyl; or a derivative of the compound selected from N-oxide derivatives, prodrug derivatives, protected derivatives, isomers, and mixtures of isomers of the compound; or a pharmaceutically acceptable salt or solvate of the compound or the derivative. Compounds of formula I and II and pharmaceuticals compositions thereof are also presented.