Patent · US Active

Compounds and compositions for use as modulators of tau aggregation and alleviation of tauopathies

US8455687B2 · kind B2 · utility

4Cited by
0References
7Claims
0Family size

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Inventors

Key dates

Filing dateJan 20, 2011
Grant dateJun 4, 2013
Priority date—
Expiry dateOct 28, 2031

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07D491/08
  • WIPO fieldOrganic fine chemistry
  • WIPO sectorChemistry

Abstract

This invention relates to the use of bis- and tris-dihydroxyaryl compounds as well as sulfonamides, heteroaryls, tricycloalkyl and their analogs and pharmaceutically acceptable salts, for modulating tau aggregation and alleviating tauopathies, such as Alzheimer's disease (AD), Pick's disease (PiD), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and familial frontotemporal dementia/Parkinsonism linked to chromosome 17 (FTDP-17), amyotrophic lateral sclerosis/Parkinsonism-dementia complex, argyrophilic grain dementia, dementia pugilistic, diffuse neurofibrillary tangles with calcification, progressive subcortical gliosis and tangle only dementia.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.