Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases

US8460659B2 · kind B2 · utility

Assignee

• JANSSEN BIOTECH, INC. · US

Inventors

• Mark Cunningham · Kennett Square, US
• Yiqing Feng · Chesterfield, US
• Katharine Heeringa · Spring House, US
• Jinquan Luo · Malvern, US
• Robert Rauchenberger · Martinsried, DE
• Mark Rutz · Martinsried, DE
• Lani San Mateo · Radnor, US
• Robert Sarisky · Lansdale, US
• Vedrana Stojanovic-Susulic · Princeton Junction, US
• Raymond Sweet · Via Enrico Fermi, US
• Fang Teng · Radnor, US
• Alexey Teplyakov · Spring House, US
• Linda Wu · Sunnyvale, US
• Sheng-Jiun Wu · Broomall, US

Key dates

• Filing date: Sep 12, 2011
• Grant date: Jun 11, 2013
• Expiry date: Sep 12, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Toll Like Receptor 3 (TLR3) antibody antagonists, polynucleotides encoding TLR3 antibody antagonists or fragments thereof, and methods of making and using the foregoing are disclosed.