Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

US8460708B2 · kind B2 · utility

Assignee

• Angiodevice International GmbH · CH

Inventors

• George Y. Daniloff · Los Altos, US
• Louis C. Sehl · Redwood City, US
• Olof Mikael Trollsas · San Jose, US
• Jacqueline A. Schroeder · Redwood City, US
• David Gravett · Palo Alto, US
• Philip M. Toleikis · Vancouver, CA

Key dates

• Filing date: Oct 24, 2011
• Grant date: Jun 11, 2013
• Expiry date: Oct 24, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Kits comprising dry power compositions are provided that readily crosslink in situ to provide crosslinked biomaterials. The dry powder composition contains at least two biocompatible, non-immunogenic components having reactive groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Exemplary uses for the crosslinked biomaterials include tissue augmentation, biologically active agent delivery, bioadhesion, and prevention of adhesions following surgery or injury.