Patent · US Active

Allosteric control of proteins by manipulating mechanical tension

US8460870B2 · kind B2 · utility

9Cited by

0References

17Claims

0Family size

Assignee

The Regents of the University of California · US

Inventors

Giovanni Zocchi · Los Angeles, US
Brian Choi · Los Angeles, US

Key dates

Filing date	Jul 20, 2011
Grant date	Jun 11, 2013
Priority date	—
Expiry date	Jul 20, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K1/1136
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion of the polypeptide, and altering the mechanical tension of the polymer, thereby altering the conformation of the polypeptide. The alteration of the conformation of the polypeptide may increase or decrease the binding affinity of the polypeptide for a substrate bound by the polypeptide, or alter the catalytic rate of an enzyme. Typically, the polymer is a polynucleotide or polypeptide.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.