Patent · US Active

Methods of specifying mesodermal, endodermal and mesoendodermal cell fates

US8460928B2 · kind B2 · utility

2Cited by

0References

14Claims

0Family size

Assignee

AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH · SG

Inventors

Manjiri Bakre · Savanuru, IN
Lawrence Stanton · Singapore, SG

Key dates

Filing date	Oct 25, 2006
Grant date	Jun 11, 2013
Priority date	—
Expiry date	Mar 30, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2506/02
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

We disclose a method for producing a mesodermal or a endodermal cell from a pluripotent stem cell, the method comprising activating a Wnt signalling pathway in the pluripotent stem cell. In some embodiments, the pluripotent stem cell is in a substantially 2 dimensional configuration, such as a monolayer, for at least a portion of the time when the Wnt signalling pathway is activated.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.