Pteridines and their use as agrochemicals

US8461164B2 · kind B2 · utility

Assignee

• DOW AGROSCIENCES LLC · US

Inventors

• William K. Brewster · Indianapolis, US
• David A. Demeter · Fishers, US
• W. Randal Erickson · Carmel, US
• Christian T. Lowe · Westfield, US
• Carla J. R. Klittich · Zionsville, US
• Jaime S. Nugent · Brownsburg, US
• Brent J. Rieder · Greenfield, US
• Thomas L. Siddall · Zionsville, US
• Chenglin Yao · Westfield, US
• Carla N. Yerkes · Crawfordsville, US
• Yuanming Zhu · Carmel, US

Key dates

• Filing date: Aug 31, 2009
• Grant date: Jun 11, 2013
• Expiry date: Aug 31, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D475/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present disclosure relates to 1- or 2-(4-(aryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and 1- or 2-(4-(heteroaryloxy)-phenyl)ethylamino-, oxy- or sulfanyl)pteridines and their use as agrochemicals and animal health products. More specifically, the invention provides new compounds of the formula (I-A):wherein: R is H, CH3, phenyl, or a heterocycle comprising a 5 or 6 membered single ring or a fused ring system comprising at least one 5 or 6 membered heterocycle optionally substituted with H, halo, lower alkyl, lower alkoxy, benzyloxy, lower alkenyl, lower alkynyl, haloalkyl, haloalkoxy, NO2, CN, lower alkoxycarbonyl, lower alkylcarbonyl, lower alkyl-SOq, and aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl. Z is H, a C—C single bond, CH2, NH, O, S, CN, CH2O, OCH2, CH2CH2O, or OCH2CH2: m is 4; p is 0 or 1; q is an integer from 0 to 2; R1 is independently H, halo, lower alkyl, lower alkenyl, lower alkynyl, hydroxy, lower alkoxy, haloalkyl, haloalkoxy, NO2, CN, lower alkylcarbonyl, lower alkoxycarbonyl, mercapto, lower alkylthio, aldoximes and lower alkyloximes, optionally substituted on oxygen by lower alkyl; Y is a C—C single bond, C(R5…