1-pyrazolo[4,3-c]isoquinoline derivatives, preparation thereof and therapeutic use thereof

US8461175B2 · kind B2 · utility

Assignee

• Sanofi-Aventis · FR

Inventors

• Georges Delettre · Paris, FR
• Stephanie Deprets · Paris, FR
• Frank Halley · Romford, GB
• Laurent Schio · Paris, FR
• Fabienne Thompson · Paris, FR

Key dates

• Filing date: Apr 22, 2010
• Grant date: Jun 11, 2013
• Expiry date: Apr 22, 2030

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a compound of formula (I), where: R1 is a phenyl group optionally substituted by one or more halogen atoms; R2 is: a hydrogen atom or a halogen atom or a cyano group; a —C(═O)Y group where Y is a hydrogen atom, or a —NH2 or —OR3 group; a —C(═S)NH2 group; a —C(═NH)NH—OH group; a —CH2OH or —CH2F group; a —CH═N—OH group; a —CH═CH2 or —C═C—R3 group; a H or H R1 group being a hydrogen or (C1-C4)alkyl group; R3 is a hydrogen atom or (C1-C4)alkyl group; and R4 is a —NH2, (C1-C4)alkyl, (C1-C4)fluoroalkyl or (C3-C7)cycloalkyl group.