(1R, 1′R)-atracurium salts separation process
US8461338B2 · kind B2 · utility
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15References
21Claims
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Key dates
| Filing date | Mar 5, 2008 |
| Grant date | Jun 11, 2013 |
| Priority date | — |
| Expiry date | Sep 16, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/027
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention provides an improved method of chromatographically separating the isomers of (1R,rR)-atracurium salts by high-performance liquid chromatography (HPLC), in the absence of a strong acid. The separation is preferably performed on a silica gel HPLC column using an eluent containing an organic solvent, a polar aprotic co-solvent and a weak organic acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.