System for differential determination of a proteolytic enzyme level in a bodily fluid
US8465635B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 7, 2006 |
| Grant date | Jun 18, 2013 |
| Priority date | — |
| Expiry date | Apr 13, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/974
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The system includes: an assortment (10) of sensors (10a, 10b, 10c), wherein the working electrode (14a) of each sensor is covered with a specific reagent of a given proteolytic enzyme, including a substrate capable of releasing leaving groups (LG) via the action of the enzyme; a measuring apparatus (20) having an electronic circuit imposing a current, whose intensity or voltage may or may not be variable, between the electrodes, and for receiving in return a signal representative of the release of the LG; and an electronic apparatus (30) for processing the transmitted signal and displaying, on a display screen (32), an indication representative of the release of the LG as a function of time. The system may be used to determine, in a plasma or whole blood sample, factors responsible for a coagulation anomaly.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.