Multi-drug ligand conjugates
US8465724B2 · kind B2 · utility
12Cited by
99References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 18, 2006 |
| Grant date | Jun 18, 2013 |
| Priority date | — |
| Expiry date | Mar 17, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described herein are compounds, pharmaceutical compositions and methods for treating pathogenic cell populations in a patient. The compounds described herein include conjugates of a plurality of cytotoxic drugs and vitamin receptor binding ligands. The plurality of drugs may be the same or different. Similarly, the vitamin receptor binding ligands may be the same or different. The conjugates also include a linker that is formed from one or more spacer linkers, heteroatom linkers, and releasable linkers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.