Methods for determining heptocellular carcinoma subtype and detecting hepatic cancer stem cells

US8465917B2 · kind B2 · utility

Assignees

• The Ohio State University Research Foundation · US
• The United States of America as Represented by The Secretary of the Department of Health and Human Services National Institutes of Health Office of Technology Transfer · US

Inventors

• Xin Wang · Beijing, CN
• Junfang Ji · Bethesda, US
• Taro Yamashita · Rifu, JP
• Carlo M. Croce · Philadelphia, US

Key dates

• Filing date: Jun 9, 2008
• Grant date: Jun 18, 2013
• Expiry date: Sep 2, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/178
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention provides a method of determining an HCC subtype in a subject comprising a) obtaining a sample from the subject, b) assaying the sample to detect the expression of 1 or more biomarkers, and c) correlating the expression of the biomarkers with an HCC subtype in a subject. The invention further provides methods of detecting HCC stem cells in a sample. Additionally, the invention provides methods and compositions for treating subjects with HCC that take advantage of the biomarkers associated with HCC stem cells.