Topical compositions containing phosphorylated polyphenols

US8465973B2 · kind B2 · utility

Assignees

• Estee Lauder Coordination Center N.V. · BE
• AJINOMOTO OMNICHEM · BE

Inventors

• Lieve Declercq · Ekeren, BE
• Hugo Corstjens · Maaseik, BE
• Daniel H. Maes · Huntington, US
• Willy Van Brussel · Wetteren, BE
• Geert Schelkens · Wetteren, BE

Key dates

• Filing date: Jun 9, 2009
• Grant date: Jun 18, 2013
• Expiry date: Jun 9, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides topical compositions containing phosphorylated polyphenols in combination with a topically acceptable carrier. The compositions of the invention provide a means for delayed delivery of the polyphenol to keratinous tissues, such as skin, hair and nails, with enzymes of the keratinous tissue dephosphorylating the polyphenol, and returning it to its native active form. The compositions are particularly useful in the regulation of skin conditions. the phosphorylated stilbene is a phosphorylated resveratrol or a phosphorylated resveratrol derivative.