TFPI inhibitors and methods of use

US8466108B2 · kind B2 · utility

Assignees

• Baxter International Inc. · US
• Baxter Healthcare SA · CH

Inventors

• Michael Dockal · Wien, AT
• Hartmut Ehrlich · Paris, FR
• Friedrich Scheiflinger · Wien, AT
• Ulf Reimer · Berlin, DE
• Ulrich Reineke · Berlin, DE
• Thomas Polakowski · Berlin, DE
• Eberhard Schneider · Wolfenbüttel, DE

Key dates

• Filing date: Dec 21, 2009
• Grant date: Jun 18, 2013
• Expiry date: Apr 10, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides peptides that bind Tissue Factor Pathway Inhibitor (TFPI), including TFPI-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a TFPI, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, and/or treat a blood coagulation disorder in a subject.