Dipeptidyl peptidase IV inhibitors

US8466145B2 · kind B2 · utility

Assignee

• ORCHID CHEMICALS & PHARMACEUTICALS LIMITED · IN

Inventors

• Gopalan Balasubramanian · Chennai, IN
• Sukumar Sakamuri · San Diego, US
• Gajendra Singh · Chennai, IN
• Sivanesan Dharmalingam · Seoul, KR
• Franklin Pooppady Xavier · Chennai, IN
• Shridhar Narayanan · Chennai, IN
• Jeyamurugan Mookkan · Chennai, IN
• Jeganatha Sivakumar Balasubramanian · Chennai, IN
• Agneeswari Rajalingam · Chennai, IN
• Jayanarayan Kulathingal · Chennai, IN

Key dates

• Filing date: Jan 7, 2010
• Grant date: Jun 18, 2013
• Expiry date: Jan 30, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Described are novel compounds of the Formula (I), their derivatives, analogs, tautomeric forms, regioisomers, stereoisomers, polymorphs, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites and prodrugs thereof. These compounds are effective in lowering blood glucose, serum insulin, free fatty acids, cholesterol, triglyceride levels; treatment of obesity, inflammation, autoimmune diseases such as multiple sclerosis, rheumatoid arthritis; treatment and/or prophylaxis of type II diabetes. These compounds are more particularly dipeptidyl peptidase (DPP IV) inhibitors.