Polypeptides, cyclic polypeptides and pharmaceutical comprising thereof for non invasive specific imaging of fibrosis

US8466258B2 · kind B2 · utility

Assignees

• INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) · FR
• UNIVERSITÉ PARIS DIDEROT—PARIS 7 · FR

Inventors

• Martine Jandrot-Perrus · Vanves, FR
• Julien Muzard · Paris, FR
• Philippe Billiald · Paris, FR
• Dominique LE GULUDEC · Paris, FR
• Laure Sarda · Paris, FR
• Alain Meulemans · Paris, FR

Key dates

• Filing date: Dec 11, 2008
• Grant date: Jun 18, 2013
• Expiry date: Nov 20, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/70503
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to diagnostic imaging and in particular to the diagnostic imaging of fibrosis. More particularly, the present invention provides a polypeptides, cyclic polypeptides and pharmaceutical compositions suitable for the non-invasive visualization of fibrosis. The polypeptide of the invention may comprise an amino acid sequence consisting of: X1-X2-M-H-G-L-X7-L-X9-X10-D-E (SEQ ID NO: 1) wherein amino acid X1 is R, F or P; amino acid X2 is F or V; amino acid X7 is Q, H or L; amino acid X9 is W or G and amino acid X10 is A or D.