Therapeutic antibody purification method and method of use
US8466265B2 · kind B2 · utility
1Cited by
3References
14Claims
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Key dates
| Filing date | Oct 2, 2008 |
| Grant date | Jun 18, 2013 |
| Priority date | — |
| Expiry date | Aug 4, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/21
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of preparing anti-b amyloid immunoglobulin involves treating human plasma anti-b amyloid immunoglobulin under alkaline conditions, such as at pH 10.25 to 11.75 using diethylamine HCl, to dissociate b amyloid protein therefrom. Typically, the anti-b amyloid immunoglobulin is present in human immunoglobulin preparations obtained from plasma or serum. Anti-b amyloid immunoglobulin prepared by the method is substantially free of b amyloid protein and has therapeutic activity in compositions and/or methods for treating a disease or condition associated with b amyloid plaques, such as Alzheimer's disease.
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