Compounds and processes for preparing substituted aminomethyl-2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-ones

US8466296B2 · kind B2 · utility

Assignee

• Ligand Pharmaceuticals Incorporated · US

Inventors

• Zhe Wang · Xiangtan City, CN
• Andrew J. Staab · Middletown, US
• Christopher Seekamp · Brookfield, US
• George P. Luke · Clinton, US

Key dates

• Filing date: Mar 26, 2008
• Grant date: Jun 18, 2013
• Expiry date: Mar 25, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/056
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Processes and intermediates are provided for the preparation of substituted aminomethyl 2,3,8,9-tetrahydiO-7H-1,4-dioxino[2.3-e]indo]-8-ones of the Formula (A) wherein the variables n, R and R3 are as described herein. Such compounds are useful, for example, as dopamine receptor agonists.