High selectively polymeric adsorbent based on the hydrogen bonding interaction and the use thereof in isolation and purification of active components from gingko biloba extract
US8466298B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 12, 2009 |
| Grant date | Jun 18, 2013 |
| Priority date | — |
| Expiry date | Feb 14, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T428/2982
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are a kind of high selectivity polymeric adsorbents with amide functional groups based on the hydrogen bonding interaction, which is prepared by adequately swelling a DVB-co-MA copolymer of 6% crosslinking degree as the initial resin with dimethyl formamide, performing an amination reaction by adding a diamine, soaking the dried resultant yellow resin with an acylating agent that is a dianhydride, and performing an acylation reaction to obtain the polymeric adsorbent with amide functional groups of the invention. The polymeric adsorbent of the invention can be used to effectively isolate and purify the active ingredients, i.e., flavones and lactones, from the extract of ginkgo leaf.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.