Humanised antibodies with anti-tumour activity

US8470320B2 · kind B2 · utility

Assignee

• Cephalon Australia Pty. Ltd. · AU

Inventors

• Adam Clarke · Chatswood, AU
• Anthony G. Doyle · Chatswood, AU
• Philip Anthony Jennings · Chatswood, AU
• Norbert Kienzle · Parramatta, AU
• Matthew Pollard · Chatswood, AU

Key dates

• Filing date: Mar 16, 2010
• Grant date: Jun 25, 2013
• Expiry date: May 23, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/734
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides humanized antibodies and binding domains thereof with anti-tumor activity. In particular the humanized antibodies have specific binding to and direct killing of human colon tumor cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumor models.