PSMA antibodies and uses thereof

US8470330B2 · kind B2 · utility

Assignees

• PSMA Development Company, LLC · US
• Amgen Fremont Inc. · US

Inventors

• Paul J. Maddon · Scarsdale, US
• Gerald P. Donovan · Kittery, US
• William Olson · Ossining, US
• Norbert Schuelke · East Walpole, US
• Jason Gardner · Wellesley, US
• Dangshe Ma · Millwood, US
• Jaspal Singh Kang · Surrey, CA
• Larry Green · San Francisco, US

Key dates

• Filing date: Jul 28, 2010
• Grant date: Jun 25, 2013
• Expiry date: Jul 28, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/622
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.