Patent · US Active

Methods of predicting resistance or sensitivity to therapies for cancer

US8470534B2 · kind B2 · utility

0Cited by
1References
9Claims
0Family size

Inventors

Key dates

Filing dateDec 3, 2007
Grant dateJun 25, 2013
Priority date—
Expiry dateOct 3, 2029

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q2600/158
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

The present application is directed to methods of predicting the resistance of a tumor to molecularly targeted therapy and methods of predicting sensitivity of a tumor to DNA damaging therapy. The methods include: a) determining the level of expression of plurality of genes regulated by retinoblastoma tumor supressor (RB) in the individual, and b) comparing the level of expression of the plurality of genes regulated by RB in the individual with a level of expression of the plurality of genes regulated by RB in a control. The application is also directed to an RNA expression profile for the loss of RB.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.