Patent · US Active

Ketoreductase polypeptides for the production of azetidinone

US8470572B2 · kind B2 · utility

15Cited by

22References

9Claims

0Family size

Assignee

Codexis, Inc. · US

Inventors

Onorato Campopiano · Hayward, US
Emily Mundorff · Garden City, US
Birthe Borup · Wesel, DE
Rama Voladri · Milpitas, US

Key dates

Filing date	Aug 8, 2012
Grant date	Jun 25, 2013
Priority date	—
Expiry date	Aug 8, 2032

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY02P20/52
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.