Substituted heterocyclylbenzylpyrazoles and use thereof

US8470811B2 · kind B2 · utility

Assignee

• Bayer Intellectual Property GmbH · DE

Inventors

• Michael Härter · Wixom, US
• Hartmut Beck · Wuppertal, DE
• Susanne Greschat · Goldkronach, DE
• Peter Ellinghaus · Melle, DE
• Kerstin Berhörster · Essen, DE
• Joachim Schuhmacher · Wuppertal, DE

Key dates

• Filing date: May 9, 2011
• Grant date: Jun 25, 2013
• Expiry date: May 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application relates to novel substituted 1-[3-(heterocyclyl)benzyl]-1H-pyrazole derivatives, to processes for preparation thereof, to use thereof for treatment and/or prevention of diseases and to use thereof for production of medicaments for treatment and/or prevention of diseases, more particularly for treatment and/or prevention of hyperproliferative and angiogenic diseases and those diseases which arise from metabolic adaptation to hypoxic states. Such treatments can be effected in the form of monotherapy or else in combination with other medicaments or further therapeutic measures.