Saturated bicyclic heterocyclic derivatives as SMO antagonists

US8470823B2 · kind B2 · utility

Assignee

• Istituto di Recerche di Biologia Molecolare P. Angeletti S.R.L. · IT

Inventors

• Danila Branca · Pomezia, IT
• Federica Ferrigno · Pomezia, IT
• Jose Ignacio Martin Hernando · Pomezia, IT
• Philip Jones · Houston, US
• Olaf Kinzel · Heidelberg, DE
• Savina Malancona · Pomezia, IT
• Ester Muraglia · Roma, IT
• Maria Cecilia Palumbi · Roma, IT
• Giovanna Pescatore · Cosenza, IT
• Rita Scarpelli · Pomezia, IT

Key dates

• Filing date: Aug 28, 2009
• Grant date: Jun 25, 2013
• Expiry date: Dec 13, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.