Patent · US Active

Episomal fusion gene

US8470826B2 · kind B2 · utility

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0References

4Claims

0Family size

Assignees

VIB VZW · BE
K.U. Leuven Research & Development · BE

Inventors

Jan Cools · Leuven, BE
Anne Hagemeijer · Pellenberg, BE
Peter Marynen · Herent, BE

Key dates

Filing date	Jun 15, 2010
Grant date	Jun 25, 2013
Priority date	—
Expiry date	Mar 29, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N9/1205
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention relates to an episomal structure expressing a functional oncogene, whereby said oncogene is a fusion gene of two chromosomal gene fragments. More specifically, the invention relates to a NUP214-ABL1 fusion product, important in the development of T-cell acute lymphoblastic leukemia, to methods to detect the fusion and to methods to prevent the oncogenic activity of said fusion product.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.