Hydrochloride salts of 8-[{1-(3,5-Bis-trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one and preparation process therefor

US8470842B2 · kind B2 · utility

Assignee

• OPKO Health, Inc. · US

Inventors

• Mengwei Hu · Hackettstown, US
• Sunil Paliwal · Manalapan, US
• Neng-Yang Shih · Lexington, US
• Frank Bruno Guenter · Thalwil, CH
• Ingrid Mergelsberg · Mahwah, US

Key dates

• Filing date: Nov 6, 2009
• Grant date: Jun 25, 2013
• Expiry date: May 25, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are hydrochloride and tosylate crystalline salt forms of (5S,8S)-8-[{(1R)-1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4.5]decan-2-one, represented by Formula I and methods of preparing the same.