7-azaindole derivatives as selective 11-β-hydroxysteroid dehydrogenase type 1 inhibitors
US8470849B2 · kind B2 · utility
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11Claims
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Key dates
| Filing date | Oct 1, 2008 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Oct 30, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to 7-azaindole derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.