Mitochondria-targeted antioxidant prodrugs and methods of use
US8470861B2 · kind B2 · utility
8Cited by
4References
4Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 27, 2010 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Jun 22, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65324
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is a mitochondria-targeted antioxidant prodrug useful for the prevention or treatment of diseases or conditions associated with mitochondrial dysfunction resulting from changes in the mitochondrial redox environment. Antioxidant prodrugs of the invention are produced by modifying an antioxidant to a fatty acid so that the resulting prodrug is targeted to and activated by an enzyme of mitochondrial fatty acid beta-oxidation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.