Mammalian sweet and amino acid heterodimeric taste receptors comprising T1R3 and T1R1

US8470970B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• THE GOVERNMENT OF THE UNITED STATES OF AMERICA · US

Inventors

• Charles S. Zuker · San Diego, US
• Jayaram Chandrashekar · San Diego, US
• Greg Nelson · San Diego, US
• Yifeng Zhang · Boston, US
• Nicholas J. P. Ryba · Bethesda, US
• Mark Hoon · Kensington, US

Key dates

• Filing date: Nov 11, 2010
• Grant date: Jun 25, 2013
• Expiry date: Nov 11, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K14/705
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising T1R3 and T1R1, two heterologous G-protein coupled receptor polypeptides from the T1R family of sensory G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.