Modular DNA-binding domains and methods of use

US8470973B2 · kind B2 · utility

Inventors

• Ulla Bonas · Bodenwerder, DE
• Jens Boch · Wunstorf, DE
• Sebastian Schornack · Cambridge, GB
• Thomas Lahaye · Usingen, DE

Key dates

• Filing date: Aug 25, 2011
• Grant date: Jun 25, 2013
• Expiry date: Aug 25, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2563/119
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide and to uses of the polypeptide and DNA in specific DNA targeting as well as to methods of modulating expression of target genes in a cell.