Ribosome structure and protein synthesis inhibitors
US8470990B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 23, 2009 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Dec 23, 2029 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.