Process for the preparation of substituted cyanophenoxy-pyrimidinyloxy-phenyl acrylate derivatives
US8471013B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 16, 2007 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Dec 11, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D239/54
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention provides a process for reacting between a phenol derivative and an aromatic substrate under phenolate forming conditions comprising the following steps: (a) reacting a phenol derivative with a base in a polar organic solvent to obtain a phenolate salt, wherein water is removed form the reaction mixture during the reaction, (b) adding the aromatic substrate to the reaction mixture obtained in step (a), (c) heating the reaction mixture of step (b) to a temperature in the range of 80° to 1300° C., preferably, 90° to 1000° C. for 2 to 7 hours to obtain a phenoxy substituted aromatic substrate, (d) removing the solvent from the mixture of step (c) and optionally further isolating an purifying the phenoxy substituted aromatic substrate. Optionally, the removal of water during step (a) is in conjunction with partial removal of the organic solvent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.