Purification of montelukast using simulated moving bed

US8471030B2 · kind B2 · utility

Assignee

• Orochem Technologies Inc. · US

Inventors

• Arun Kanti Mandal · Thane, IN
• Kamlesh Jayantilal Ranbhan · Navi Mumbai, IN
• Ganesh Gurpur Pai · Thane, IN
• Abhilesh Agarwal · Lombard, US
• Rakesh Vikraman Nair Rema · Downers Grove, US
• Asha A. Oroskar · Oak Brook, US

Key dates

• Filing date: Dec 6, 2010
• Grant date: Jun 25, 2013
• Expiry date: Sep 7, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/18
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This invention concerns generally with a process for purifying crude pharmaceutical compositions, wherein the crude pharmaceutical composition comprises a sodium salt of Montelukastand more particularly relates to a process for the production of pharmaceutically pure preparations of Montelukast sodium using simulated moving bed technology, without requiring an intermediate acid formation step to separate isomers and to remove impurities.