Patent · US Active

Method for producing chiral α,β-epoxy ketones

US8471046B2 · kind B2 · utility

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11Claims

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Assignee

Studiengesellschaft Kohle gGmbH · DE

Inventors

Benjamin List · Wetter (Ruhr), DE
Corinna Reisinger · Bellinzona, CH
Xingwang Wang · Tongji, CN

Key dates

Filing date	Mar 12, 2009
Grant date	Jun 25, 2013
Priority date	—
Expiry date	Oct 24, 2029

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D301/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

A process is claimed for the enantioselective epoxidation of α,β-unsaturated ketones, in which a compound of the general formula I,is reacted with an oxidizing agent to form α,β-epoxy ketones of the general formula II,in which R1, R2, R3 are as defined above. The α,β-epoxy ketones of the general formula II can be obtained in good yields and outstanding enantioselectivities from α,β-unsaturated ketones of the general formula I by epoxidation with hydrogen peroxide in the presence of a chiral catalyst, such as amino compounds and their acid addition salts.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.