Sitagliptin intermediates, preparation methods and uses thereof
US8471057B2 · kind B2 · utility
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13Claims
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Key dates
| Filing date | Sep 25, 2010 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Sep 25, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C229/34
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to Sitagliptin intermediate and preparation method and use thereof. The method comprises reacting compound of formula (II) and trifluorobromobenzene with a Grignard reagent by a Grignard reaction to obtain a compound of formula (I). Compound of formula (I) is a new intermediate compound for the synthesis of Sitagliptin. Compound of formula (I) can be easily used for preparing another important intermediate compound of formula (V) for the synthesis of Sitagliptin. The structures of the compounds mentioned above are as the following:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.