In vivo measurement of mitochondrial function
US8473036B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 1, 2009 |
| Grant date | Jun 25, 2013 |
| Priority date | — |
| Expiry date | Jul 10, 2029 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/0075
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
Disclosed herein are devices for assessing mitochondrial function in a living subject comprising a catheter comprising a sheath defining a lumen, a distal end, and a proximal end comprising a light guide for radiating light onto a target within the subject and for receiving a fluorescence signal from the target; a light source, wherein the catheter is adapted for transmitting light from the light source to the light guide; and, a detector for receiving the fluorescence signal from the light guide and for correlating the fluorescence signal to the mitochondrial function of the target. Also disclosed are methods for assessing mitochondrial function in a living subject comprising placing a catheter proximate to a site of interest within the subject; using the catheter to acquire fluorescence signals from cells at the site of interest; and, correlating the fluorescence signals to the mitochondrial function of the cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.