Method for multiplexed capillary electrophoresis signal cross-talk correction
US8475640B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Jan 24, 2011 |
| Grant date | Jul 2, 2013 |
| Priority date | — |
| Expiry date | Oct 14, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N27/44782
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention provides a simple method to correct cross-talk, after the data have been generated. Adjacent signals are simply subtracted from the original observed signal with a repeating process. The data processing is stopped when a predefined condition is met. By this technique, cross-talk can be reduced from >5% to less than 0.1%. And as an additional advantage, this method provides a way to correct the cross-talk without the need to know which peaks are caused by the adjacent capillary signal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.