Immunogenic reagents from west nile virus

US8475808B2 · kind B2 · utility

Assignee

• Novartis Vaccines and Diagnostics, Inc. · US

Inventors

• William H. Andrews · Reno, US
• David Chien · Emeryville, US
• Qui-Lim Choo · Corona, US
• Stephen R. Coates · Orinda, US
• Doris Coit · Petaluma, US
• Charles Robert Harrington · Tornaveen, GB
• Susan Hilt · Vacaville, US
• Michael Houghton · Berkeley, US
• Angelica Medina-Selby · San Francisco, US
• Sergio Pichuantes · Corona, US
• Yiu-Lian Fong · Lafayette, US

Key dates

• Filing date: May 21, 2004
• Grant date: Jul 2, 2013
• Expiry date: Oct 1, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Recombinant production of immunogenic West Nile Virus (WNV) proteins is described. These proteins, heterodimers comprising the proteins, fusions thereof, polynucleotides encoding the proteins, and combinations thereof, as well as antibodies produced therefrom, can be used in immunogenic compositions for preventing, treating and diagnosing WNV infection. Also described are highly sensitive ELISA and strip immunoassay methods for detecting the presence of WNV in biological samples.