Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8476013B2 · kind B2 · utility
12Cited by
123References
20Claims
0Family size
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Key dates
| Filing date | Sep 16, 2009 |
| Grant date | Jul 2, 2013 |
| Priority date | — |
| Expiry date | Mar 8, 2031 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/385
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Provided are compositions and processes that utilize genomic regions differentially methylated between a mother and her fetus to separate, isolate or enrich fetal nucleic acid from a maternal sample. The compositions and processes described herein are useful for non-invasive prenatal diagnostics, including the detection of chromosomal aneuplodies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.