Complement factor H-based assays for serum bactericidal activity against Neisseria meningitidis

US8476032B2 · kind B2 · utility

Assignees

• Children's Hospital & Research Center at Oakland · US
• Novartis Vaccines and Diagnostics, Inc. · US
• University of Massachusetts · US

Inventors

• Dan M. Granoff · Berkeley, US
• JoAnne Welsch · Emeryville, US
• Sanjay Ram · Worcester, US

Key dates

• Filing date: Aug 26, 2009
• Grant date: Jul 2, 2013
• Expiry date: Dec 21, 2030

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2469/20
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Assays for detection of bactericidal anti-Neisserial antibodies using a factor H polypeptide having a human amino acid sequence that mediates binding to Neisserial factor H binding protein (fHBp) are provided, as well as non-human animal models of Neisserial infection.