Patent · US Active

Device for measuring nanometer level pattern-dependent binding reactions

US8476065B2 · kind B2 · utility

1Cited by

11References

18Claims

0Family size

Assignee

The Trustees of Columbia University in the City of New York · US

Inventors

Michael Sheetz · Avon, US
Samuel Jonas Wind · White Plains, US

Key dates

Filing date	Apr 13, 2006
Grant date	Jul 2, 2013
Priority date	—
Expiry date	Jan 3, 2029

Classification

Technology area (CPC G)Physics
CPC primaryG01N33/6803
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The present invention is directed to a device comprising (a) a substrate having a surface and (b) an ordered array of posts over the surface, wherein the posts are capable of binding a protein or small molecule ligand, and wherein the pitch between adjacent posts is less than about 100 nm. The invention is also directed to methods for identifying the presence of an analyte in a fluid and to methods for measuring relative binding specificity or affinity between an analyte in a fluid and the posts, using the device of the present invention.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.