Modified AAV capsid polypeptides

US8476418B2 · kind B2 · utility

Assignees

• Deutsches Krebsforschungszentrum · DE
• RUPRECHT - KARLS - UNIVERSITÄT HEIDELBERG · DE

Inventors

• Oliver Mueller · Heikendorf, DE
• Hugo Katus · Heidelberg, DE
• Karl Varadi · Heidelberg, DE
• Jürgen Kleinschmidt · Hersbruck, DE

Key dates

• Filing date: May 28, 2010
• Grant date: Jul 2, 2013
• Expiry date: May 28, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2810/40
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention is concerned with the provision of a polynucleotide encoding an AAV capsid polypeptide comprising an inserted peptide and a vector comprising said polynucleotide. Moreover, contemplated is a host cell comprising said polynucleotide or vector, a method for the manufacture of said capsid polypeptide as well as said polypeptide. Further included is an antibody specifically binding to said polypeptide and a medicament comprising said polynucleotide, vector, polypeptide, or antibody. Also contemplated are the use of said polynucleotide, vector, polypeptide, or antibody for the manufacture of a medicament for the treatment of vascular disease and a method for the identification of a compound binding to said polypeptide.