Protein kinase modulators and method of use

US8476434B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• Stephanie Geuns-Meyer · Medford, US
• Brian L. Hodous · Cambridge, US
• Stuart C. Chaffee · Philadelphia, US
• Paul Tempest · Somerville, US
• Ning Xi · Newbury Park, US
• Phillip R. Olivieri · Boston, US
• Joseph L. Kim · Wayland, US
• Steven Bellon · Wellesley, US
• Xiaotian Zhu · Newton, US
• Yuan Cheng · Newbury Park, US
• Brian K. Albrecht · Cambridge, US
• Vinod F. Patel · Acton, US
• Victor J. Cee · Thousand Oaks, US
• Karina Romero · Cambridge, US
• Hanh Nho Nguyen · North Palm Beach, US
• Holly L. Deak · Brookline, US
• Rebecca Elizabeth Johnson · Arlington, US

Key dates

• Filing date: Nov 22, 2010
• Grant date: Jul 2, 2013
• Expiry date: Nov 22, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to chemical compounds having a general formula Iwherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of these kinases. For example, the compounds are capable of modulating kinase enzymes thereby influencing the process of angiogenesis and treating angiogenesis-related diseases and other proliferative disorders, including cancer and inflammation. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of protein kinases.