Microbubbles and methods for oxygen delivery

US8481077B2 · kind B2 · utility

Assignees

• The Trustees of Columbia University in the City of New York · US
• Children's Medical Center Corporation · US

Inventors

• John Kheir · Boston, US
• Mark A. Borden · Boulder, US
• Francis X. McGowan · Wellesley, US

Key dates

• Filing date: Feb 22, 2012
• Grant date: Jul 9, 2013
• Expiry date: Feb 22, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions containing a carrier and microbubbles encapsulating one or more gases, preferably oxygen, and methods for making and using the compositions are described herein. The microbubbles contain a lipid envelope. The compositions may be administered to a patient to quickly deliver large amounts of oxygen to the patient's blood supply or directly to a tissue in need of oxygen. The compositions may be administered via injection or as a continuous infusion. The compositions contain a concentrated microbubble suspension, where the suspension contains at least 40 mL oxygen/dL suspension. The microbubbles are preferably less than 20 microns in diameter, more preferably less than 15 microns in diameter. The microbubbles described herein may be administered to a patient in an effective amount to increase in oxygen concentration in the patient's blood, and/or one or more tissues or organs.