Method for automated, large-scale measurement of the molecular flux rates of the proteome or the organeome using mass spectrometry
US8481478B2 · kind B2 · utility
10Cited by
70References
18Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 1, 2012 |
| Grant date | Jul 9, 2013 |
| Priority date | — |
| Expiry date | Mar 1, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/24
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed here is a method for measuring the kinetics (i.e., the molecular flux rates—synthesis and breakdown or removal rates) of a plurality of proteins or organic metabolites in living systems. The methods may be accomplished in a high-throughput, large-scale automated manner, by using existing mass spectrometric profiling techniques and art well known in the fields of static proteomics and static organeomics, without the need for additional biochemical preparative steps or analytic/instrumental devices.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.