Patent · US Active

Compounds for the treatment of diseases related to protein misfolding

US8481494B2 · kind B2 · utility

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18Claims

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Inventors

Thomas Schrader · San Diego, US
Katrin Hochdörffer · Glückstadt, DE
Julia März-Berberich · Essen, DE
Luitgard Nagel-Steger · Langenfeld, DE
Gal Bitan · Jerusalem, IL
Sharmistha Sinha · Ames, US

Key dates

Filing date	Jan 26, 2010
Grant date	Jul 9, 2013
Priority date	—
Expiry date	Jan 26, 2030

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to the field of protein misfolding diseases and thus to diseases which are associated with or induced by abnormal or pathogenic three-dimensional folding of proteins and/or peptides or which are linked to pathogenic conformational changes of proteins and/or peptides, such as Alzheimer's disease. Particularly, the present invention provides novel trimeric pyrazole compounds, which exhibit a therapeutic effectiveness in regard to the aforementioned protein misfolding diseases, and refers to their use for the treatment of such protein misfolding diseases, especially neurodegenerative diseases as well as to medicaments or pharmaceutical compositions comprising these compounds.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.