Antibacterial aminoglycoside analogs

US8481502B2 · kind B2 · utility

Assignee

• ACHAOGEN, INC. · US

Inventors

• James Aggen · Westwood, US
• Paola Dozzo · San Francisco, US
• Adam A. Goldblum · Berkeley, US
• Darin James Hildebrandt · Cupertino, US
• Timothy Robert Kane · Moss Beach, US
• Micah James Gliedt · Redwood City, US
• Martin S. Linsell · San Mateo, US

Key dates

• Filing date: Apr 6, 2012
• Grant date: Jul 9, 2013
• Expiry date: Apr 6, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having antibacterial activity are disclosed. The compounds have the following structure (I):including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein Q1, Q2, Q5, R1, R2, R3, Z1 and Z2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.