Micro-RNAs that control myosin expression and myofiber identity
US8481507B2 · kind B2 · utility
9Cited by
1References
32Claims
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Key dates
| Filing date | Jul 31, 2008 |
| Grant date | Jul 9, 2013 |
| Priority date | — |
| Expiry date | Oct 25, 2028 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2330/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the identification of two microRNAs, miR-499 and miR-208b, that repress fast skeletal muscle contractile protein genes. Expression of miR-499 and/or miR-208b can be used to repress fast fiber genes and activate slow fiber genes in the treatment of musculoskeletal disorders. Inhibition of miR-499 and/or miR-208b is proposed as a treatment for cardiac hypertrophy, myocardial infarction, and/or heart failure. Pharmaceutical compositions comprising antagonists and agonists of miR-499 and miR-208b function are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.