Patent · US Active

Synthesis of epothilones, intermediates thereto, analogues and uses thereof

US8481575B2 · kind B2 · utility

0Cited by

75References

6Claims

0Family size

Assignee

Sloan Kettering Institute for Cancer Research · US

Inventors

Samuel J. Danishefsky · New Haven, US
Peter Bertinato · Old Lyme, US
Dai-Shi Su · New York, US
Dongfang Meng · Morganville, US
Ting-Chao Chou · Paramus, US
Ted Kamenecka · New York, US
Erik Sorensen · Village of La Jolla, US
Aaron Balog · Lambertville, US
Kenneth A. Savin · New York, US

Key dates

Filing date	Mar 3, 2011
Grant date	Jul 9, 2013
Priority date	—
Expiry date	Mar 3, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F7/1804
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.